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Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer-related mortality worldwide. Nop2/Sun domain family member 5 (NSUN5), a conserved RNA 5-methylcytosine methyltransferase.


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GeneCards Summary for NSUN5 Gene. NSUN5 (NOP2/Sun RNA Methyltransferase 5) is a Protein Coding gene. Diseases associated with NSUN5 include Ehrlichiosis and Williams-Beuren Syndrome . Gene Ontology (GO) annotations related to this gene include RNA binding and methyltransferase activity . An important paralog of this gene is NOP2.


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NSUN5 is a conserved RNA methyltransferase belonging to the Nop2/SUN domain family. So far the only known substrate of the yeast homolog of NSUN5, Rcm1, is C2278 of 25S rRNA , while C2381 of 26S rRNA is the substrate of NSUN-5, the Caenorhabditis elegans homolog and C3782 of human NSUN5 .


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NSUN5 is downregulated in erastin-induced BMSC ferroptosis. We screened for the mRNAs and proteins of some RNA methyltransferases that were differentially expressed during BMSC ferroptosis using.


NSUN5 is the closest human homolog of Rcm1p. (A) The multiple protein

Abstract. Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in.


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NSUN5 Facilitates Viral RNA Recognition by RIG-I Receptor. Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program. Phenotypic consequences of NSUN5 deficiency in mammalian cells include decreased proliferation and size, which can be attributed to a reduction in total protein.


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NSUN5 is a conserved RNA methyltransferase belonging to the Nop2/SUN domain family. So far the only known substrate of the yeast homolog of NSUN5, Rcm1, is C2278 of 25S rRNA , while C2381 of 26S rRNA is the substrate of NSUN-5, the Caenorhabditis elegans homolog and C3782 of human NSUN5 .


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NSUN5 is just such a member of RNA methyltransferases. In Janin's model, NSUN5 showed tumor-suppressor function in vivo glioma models, and an unmethylated status of NSUN5 led to long-term survival in glioma patients . While in our study, NSUN5 promoted CRC progression. The difference may due to mechanisms in two kinds of tumors.


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The expression of NSUN5 was increased in CRC. A. From TCGA database

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