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The long C4 gene contains an endogenous retrovirus, HERV-K(C4), in its ninth intron. Approximately three-quarters of C4 genes in Caucasian populations belong to the long form. About 40 protein variants for complement C4 have been documented. 17 These proteins are segregated into two classes, the acidic C4A and the basic C4B.
An insertion of 6.4 kb is present in intron 9 of 60% of the human complement C4 genes, as well as in the C4 genes of a number of Old World primates. This insertion has the typical genomic organization of endogenous retroviruses, with the three major genes gag, pol and env flanked by long terminal re.
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The human complement C4 gene (C4A and C4B genes) locus is located in the highly polymorphic major histocompatibility complex (MHC) class III gene region on chromosome 6, which could be a short form (C4S, 14.6 kb) or a long form (C4L, 21 kb), depending on the absence or the presence of the 6.36 kb endogenous retroviral sequence HERV-K(C4) in.
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Spline motion programming, KR C4-based automation solutions are superior in every way. Furthermore, the KR C4 features intelligent, flexible and scalable appli-cation potential. High-end PLC support. The high-end SoftPLC option allows full access to the entire controller I / O system and has a high runtime performance. It allows the I / O hand-
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The complement C4 locus is in the class III region of the MHC, and exhibits copy number variation. Complement C4 null alleles have shown association with a number of diseases including systemic lupus erythematosus (SLE). However, most studies to date have used protein immunophenotyping and not direct interrogation of the genome to determine C4.
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The KR C4 controller is a pioneer for the automation of today and tomorrow. It reduces costs in integration, maintenance and servicing. At the same time, the long-term efficiency and flexibility of the systems are increased - thanks to common, open industry standards.. The KR C4 software architecture integrates Robot Control, PLC Control, Motion Control (for example KUKA.CNC) and Safety Control.
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The human complement C4 gene (C4A and C4B genes) locus is located in the highly polymorphic major histocompatibility complex (MHC) class III gene region on chromosome 6, which could be a short form (C4S, 14.6 kb) or a long form (C4L, 21 kb), depending on the absence or the presence of the 6.36 kb endogenous retroviral sequence HERV-K(C4) in.
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The impetus for the present study is that our earlier work in healthy European Americans revealed an interindividual variation in the C4 gene copy number (GCN) and dichotomies of C4 gene size and C4 protein isotypes. 33 - 38 In the central region of the human major histocompatibility complex (MHC) on each chromosome 6 (fig. 1), there can be 1.
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Results. The large study populations helped establish the distribution patterns of various C4 GCN groups. Low GCNs of C4T (C4T=2+3) and C4A deficiency (C4A=0+1) were strongly correlated with increased risk of IIM with OR equalled to 2.58 (2.28-2.91), p=5.0×10 −53 for C4T, and 2.82 (2.48-3.21), p=7.0×10 −57 for C4A deficiency. Contingency and regression analyses showed that among.
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Between the two sequences for the endogenous retrovirus HERV-K(C4) in intron 9, there are 14 SNPs and three single-nucleotide indels. The sequences that determine the C4A and C4B reactivity, the serological properties such as the Rg and Ch determinants, and most of the polymorphic amino acid residues in human C4A and C4B clustered at the C4d.
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Complement component C4 (C4) is a highly variable complement pathway gene situated ∼500 kb from DRB1 and DQB1, the genes most strongly associated with many autoimmune diseases. Variations in C4 copy number (CN), length, and isotype create a highly diverse gene cluster in which insertion of an endogenous retrovirus in the ninth intron of C4.
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The HERVK (C4) insertion that contributes to the long form of the C4 gene in humans and nonhuman primates ( Schneider et al. 2001a) expresses antisense transcripts that may act against exogenous.
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The diversities and polymorphisms of the mouse homologues Slp and C4 proteins are described and contrasted with their human homologues. The human C4 genes are located in the MHC class III region on chromosome 6. Each human C4 gene consists of 41 exons coding for a 5.4-kb transcript. The long gene is 20.6 kb and the short gene is 14.2 kb.
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Page 1 KUKA Deutschland GmbH Controller KR C4 compact Specification KR C4 com- pact Issued: 20.04.2018 Version: Spez KR C4 compact V10.; Page 2 Subject to technical alterations without an effect on the function. KIM-PS5-DOC Translation of the original documentation Publication: Pub Spez KR C4 compact (PDF) en Book structure: Spez KR C4 compact V8.1 Version: Spez KR C4 compact V10 Issued: 20..
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The KR C4 controller is a pioneer for the automation of today and tomorrow. It reduces costs in integration, maintenance and servicing. At the same time, the long-term efficiency and flexibility of the systems are increased - thanks to common, open industry standards.. The KR C4 software architecture integrates Robot Control, PLC Control, Motion Control (for example KUKA.CNC) and Safety Control.