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Pharmacology. Dolutegravir acts by impairing the function of the HIV integrase-DNA complex to which it was chemically synthesized to bind.16 It is rapidly absorbed, achieving maximal blood concentration hours after ingestion and, with a terminal half-life of 12 hours, requires once-daily administration without pharmacological enhancement.17-19 There is minimal urinary excretion as it is.
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Menurut Christoper & Sharon (2015), menjelaskan dolutegravir, INSTI terbaru, adalah agen antiretroviral yang efektif untuk pasien yang belum pernah menggunakan pengobatan dan pasien yang berpengalaman dengan pengobatan yang terinfeksi HIV. Hal ini didorong oleh penekanan virologi yang efektif, tolerabilitas yang baik, interaksi obat-obat yang.
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Dolutegravir is highly protein bound to human plasma proteins at ≥98.9%, and binding is independent of plasma concentration. The apparent volume of distribution ( Vd / F) following administration is estimated at approximately 17.4 L, though the absolute bioavailability ( F) of dolutegravir has not been established. 7.
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Dolutegravir adalah obat terbaru yang digunakan dalam pengobatan infeksi HIV dan AIDS. Untuk mengetahui manfaat dari risiko lebih lanjut dari obat ini, silakan berkonsultasi dengan dokter atau petugas medis yang menangani Anda. Catatan. Hello Sehat tidak menyediakan saran medis, diagnosis, atau perawatan.
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Generic Name Dolutegravir DrugBank Accession Number DB08930 Background. Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). 1 The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity. 11 Dolutegravir was developed by ViiV Healthcare and.
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Uses. Dolutegravir is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your.
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Dolutegravir is used with other medications to treat human immunodeficiency virus (HIV) infection in adults and children 4 weeks of age and older who weigh at least 6.6 lbs (3 kg). It is also used in combination with rilpivirine (Edurant) to treat HIV in certain adults to replace their current HIV medication (s) that has been taken for at least.
Structural and functional analysis of Dolutegravir. Download Scientific Diagram
Dolutegravir is an antiretroviral medication used to treat human immunodeficiency virus (HIV) infection in adults and children, as a component of antiretroviral therapy (ART) regimen. Patients with underlying hepatitis B or C are at higher risk for worsening of liver condition and reactivation of hepatitis B. Common side effects include increase in levels of serum lipase, increase in levels of.
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The World Health Organization's (WHO) latest HIV Drug Resistance (HIVDR) Report tells us where drug resistance is growing and offers recommendations for countries to monitor and respond to the potential challenges. The report shares some good news and some concerning news. It highlights high levels of HIV viral load suppression (>90%) in populations receiving dolutegravir (DTG)-containing.
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Neonate Dose. Dolutegravir (DTG) is not approved by the FDA for use in neonates. [Tivicay PD] Dolutegravir Dispersible Tablets. Infant (Aged ≥4 Weeks and Weighing ≥3 kg), Child, and Adolescent Dose. Pediatric Body Weight. Recommended Dose a of Dolutegravir Dispersible Tablets. Number of 5-mg tablets.
2D structures of (A) dolutegravir, (B) raltegravir and (C)... Download Scientific Diagram
Dolutegravir, the newest INSTI, is an effective antiretroviral agent for both treatment-naïve and treatment-experienced patients infected with HIV. This is driven by effective virologic suppression, good tolerability, infrequent drug-drug interactions, and once-daily administration. Co-formulation of dolutegravir with abacavir-lamivudine.
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Dolutegravir side effects. Stop taking dolutegravir and get emergency medical help if you have signs of an allergic reaction: fever, general ill feeling, trouble breathing, tiredness; joint or muscle pain, blisters or mouth sores, redness or swelling in your eyes; blistering or peeling skin; swelling of your face, lips, tongue, or throat. Dolutegravir may cause serious side effects.
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Dolutegravir offers numerous advantages to help in the continued pursuit of the antiretroviral therapy scale-up. The improvements in efficacy and tolerability are likely to be amplified in settings with high drug-resistance to non-nucleoside reverse transcriptase inhibitors, which are becoming more common.
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Dolutegravir can cause serious, life-threatening side effects. These include severe skin rash and allergic reactions, liver problems, and drug interactions. Contact your health care provider right away if you develop a rash while taking dolutegravir. Stop taking dolutegravir and get medical help right away if you develop a rash with any of the.
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Dolutegravir umumnya digunakan bersama beberapa obat antiretroviral lainnya untuk meningkatkan efektivitas dan mencegah kekebalan virus terhadap obat. Berikut adalah dosis dolutegravir: Dewasa: 50 mg, 1-2 kali sehari, tergantung pada kondisi pasien. Anak usia 6-<12 tahun dengan berat badan 15-<20 kg: 20 mg, sekali sehari.
Dolutegravirbased regimens result in sustained viral suppression, despite lower adherence and
Español. Based on new evidence assessing benefits and risks, the WHO recommends the use of the HIV drug dolutegravir (DTG) as the preferred first-line and second-line treatment for all populations, including pregnant women and those of childbearing potential. Initial studies had highlighted a possible link between DTG and neural tube defects.