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The aim of this study was to investigate safety of treating diabetic foot ulcers with a topically administered mesenchymal stem cell product. Individuals with diabetes, peripheral neuropathy, toe blood pressure > 39 mmHg and non-infected foot ulcers with duration of four to fifty-two weeks were screened. Participants were treated with a one-time application of a topically applied allogeneic.
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Stem cell therapy is emerging as a potential treatment for chronic wounds, and adult-derived stem cells are currently employed in several commercially available products; however, stem cell therapy is limited by the need for invasive harvesting techniques, immunogenicity, and limited cell survival in vivo.. Kirana S, Stratmann B, Prante C.
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Chandra KIRANA, Researcher | Cited by 534 | | Read 16 publications | Contact Chandra KIRANA. The expression of HLA-G by tumour cells is an established mechanism to escape recognition and immune.
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The CD4+ Tcells,CD8+ T cells, B cells, and NK cells are decreased following the declining expression of IFN-γ in CD4+ T cells and upregulated NKG2A receptors on NK cells and CD8+ Tcells[38, 39]. Patient Management As there is no targeted therapy available until now, clinicians and researchers are mobilized to findthe cure for COVID-19.
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Cell-based therapies have come into view as a new frontier in this direction and bone marrow-derived stem cells (BM-SC) are currently seen as a prospective and possible newer therapeutic option in this regard.. Kirana S, Stratmann B, Prante C, Prohaska W, Koerperich H, Lammers D, et al. Autologous stem cell therapy in the treatment of limb.
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In this review, we will be focusing on the potency of mesenchymal stem cells (MSCs) and MSC-derived secretome for treating COVID-19 patients. Fever, cough, headache, dizziness, and fatigue are the common clinical manifestations in COVID-19 patients. In mild and severe cases, cytokines are released hyper-actively which causes a cytokine storm.
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Background and aim: Despite improvements in surgical revascularisation, limitations like anatomical factors or atherosclerosis limit the success of revascularisation in diabetic patients with critical limb ischaemia. Stem cells were shown to improve microcirculation in published studies. The aim of this study was to evaluate safety, feasibility and efficacy of transplantation of bone marrow.
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The COVID-19 disease is an infection disease which affects the world in 2020. Currently, there is no definite treatment for COVID-19 patients. However, several clinical trials have been proposed to overcome this disease and one of them is using mesenchymal stem cells (MSCs) and MSC-derived secretome for treating COVID-19 patients.
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Autologous stem cell-based therapy has been proposed as a promising strategy for the treatment of topical lower extremity ulcers by pilot studies in animal models and humans, 9,12. (Lu 2011 and Kirana 2012) 18,21 or doses (Losordo 2012) 22 of stem cells used, and similarly, 2 comparisons were derived for each.
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Stem cells are characterized by their multipotency and capacity for self-renewal, and their ability to secrete proregenerative cytokines, making them a promising choice for the tissue regeneration. 1 Currently, stem cell therapy has been tested in preclinical and clinical trials in several different fields with positive clinical outcomes. 2.
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1. Introduction. Diabetic foot, a serious complication in type 2 diabetes, afflicts approximately 6% of people with diabetes worldwide [].It is associated with peripheral neuropathy or peripheral artery disease which increases risk of impaired wound healing and is the most important precursor for lower-extremity amputations [2, 3].The resulting high number of amputations has major influence on.
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S Kirana, B Stratmann, D Lammers, M Negrean, A Stirban, P Minartz, H Koerperich, M H Gastens, C Götting, W Prohaska, K Kleesiek, D Tschoepe.. We conclude that our autologous stem cell therapy is working in this patient and it is a potential new therapeutic option for diabetic patients with chronic foot ulcers induced by critical limb ischaemia.